Tretinoin in the treatment of acne

Tretinoin is a derivative of vitamin A acid, intermediate metabolites of vitamin A in the body, the anti-tumor effect of tretinoin is confirmed as one of the three findings of the international anti-cancer drugs in the 1990s, has a strong induction differentiation of tumor cells, cause much attention in the international pharmaceutical industry, the first choice of clinical drug for the treatment of acute promyelocytic leukemia, myelodysplastic (preleukemic).Tretinoin clinical evidence also show that it also have a significant effect in the treatment of acne, lichen planus, vitiligo, multiple common warts and other skin keratinization.

Vitamin A is widely used to treat a variety of skin diseases, however in the treatment of these diseases, its therapeutic dose is closed to the toxic dose, thereby greatly limiting the clinical application of vitamin A. Chemists has been transformed the chemical structure of vitamin A to obtain many types of structural analogues of vitamin A, is collectively referred to as “Retinoids”, they are primarily of vitamin A acid derivatives. The tretinoin mainly affect bone growth and epithelial metabolism, have the role of promoting keratinocyte proliferation, differentiation keratolytic, maintain skin, cornea, the normal metabolism of the cells of the upper respiratory tract and urogenital trail.

Oral or topical vitamin A acid and its derivatives can promote cell differentiation, inhibit keratinization process, reduce sebum secretion, blocking chemical carcinogens process, enhance the function package immune and free macrophages, as well as anti-inflammatory, inhibiting and killing acne rod. Vitamin A acid drugs are the main drugs of the clinical treatment of disease of abnormal skin keratinocytes, especially in the treatment of psoriasis drug has an irreplaceable position.

Studies by tretinoin manufacturer show that tretinoin is the most effective topical appropriate drugs, and works for all stages of acne. What different with most drugs for the treatment of surface pimples, the all-trans vitamin A containing an active ingredient referred to as vitamin A acid which can penetrate into the hair follicles of the skin by invasion. Accelerated sebum secrete from hair follicles, loosening the existing blockages, push it to the skin’s surface, then clear from there. Similarly, all-trans vitamin A acid can be suppressed by preventing the formation of new clogging acne appears.

If your skin is drying, you can use the cream which add all-trans vitamin A acid as cosmetic raw material, because it contains moisturizing ingredients, will not clog pores. But it also has more dry gel state, suitable for oily skin. This drug use at night after washing 15 to 20 minutes, ensure the skin is dry after applying, its best result can last at least 12 weeks.

You will see some of the snowflake shape things fall off from the top layer of the skin, it means the acne treatment is working now. Although this was rebarbative, but it only lasted for 4 to 6 weeks, so you should not stop the early treatment. If you persist on, the skin will usually with drug tolerance. If you use the all-trans vitamin A acid, your skin becomes more sensitive to sun exposure, so take preventive measures is very important. If you are in the sun exposure to serious local holiday, so I suggest you discontinuation of the treatment during the vacation, and use an SPF 15 sunscreen. Tretinoin buy online uk

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